GrippeCanadaV3, Main, Exploration, bibRecord, 000095

Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections.

Identifieur interne : 000095 ( Main/Exploration ); précédent : 000094; suivant : 000096

Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections.

Auteurs : Andrea Granados [Canada] ; Adriana Peci [Canada] ; Allison Mcgeer [Canada] ; Jonathan B. Gubbay [Canada]

Source :

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2017.

RBID : pubmed:27893998

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Coinfection (microbiology), Coinfection (pathology), Coinfection (virology), Common Cold (complications), Common Cold (pathology), Common Cold (virology), Female, Hospitalization, Humans, Infant, Infant, Newborn, Influenza, Human (complications), Influenza, Human (pathology), Influenza, Human (virology), Male, Nasopharynx (microbiology), Nasopharynx (virology), Ontario, Orthomyxoviridae (isolation & purification), Pneumococcal Infections (complications), Pneumococcal Infections (pathology), Real-Time Polymerase Chain Reaction, Respiratory Tract Infections (pathology), Respiratory Tract Infections (virology), Rhinovirus (isolation & purification), Sex Factors, Streptococcus pneumoniae (isolation & purification), Viral Load, Young Adult.
MESH :
- complications : Common Cold, Influenza, Human, Pneumococcal Infections.
- isolation & purification : Orthomyxoviridae, Rhinovirus, Streptococcus pneumoniae.
- microbiology : Coinfection, Nasopharynx.
- pathology : Coinfection, Common Cold, Influenza, Human, Pneumococcal Infections, Respiratory Tract Infections.
- virology : Coinfection, Common Cold, Influenza, Human, Nasopharynx, Respiratory Tract Infections.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Hospitalization, Humans, Infant, Infant, Newborn, Male, Ontario, Real-Time Polymerase Chain Reaction, Sex Factors, Viral Load, Young Adult.

Abstract

BACKGROUND

The role of viral load in respiratory viral infection is unclear. It is proposed that the viral load of some, but not all respiratory viruses correlate with disease severity.

OBJECTIVES

We aimed to determine if an association exists between viral loads among patients in ambulatory settings, compared to those requiring hospitalization/intensive care unit (ICU) admission with influenza A/H3N2, influenza B, or human rhinovirus (HRV); we also explored the impact of age, gender and co-detection of Streptococcus pneumoniae on patient setting. We hypothesized that hospitalized/ICU patients have higher respiratory virus viral loads compared to ambulatory (e.g. walk-in clinics, family practices)/ER patients.

STUDY DESIGN

We quantified viral load by in-house real-time RT-PCR in 774 nasopharyngeal swabs with influenza A/H3N2, or B or HRV viruses from various patient settings in Ontario, Canada.

RESULTS

Mean viral load (log

CONCLUSION

When compared to ambulatory/ER patients, viral load was higher in hospitalized/ICU patients with influenza B, but not influenza A or HRV.

DOI: 10.1016/j.jcv.2016.11.008
PubMed: 27893998

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000115
to stream Main, to step Curation: 000115

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The role of viral load in respiratory viral infection is unclear. It is proposed that the viral load of some, but not all respiratory viruses correlate with disease severity.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>We aimed to determine if an association exists between viral loads among patients in ambulatory settings, compared to those requiring hospitalization/intensive care unit (ICU) admission with influenza A/H3N2, influenza B, or human rhinovirus (HRV); we also explored the impact of age, gender and co-detection of Streptococcus pneumoniae on patient setting. We hypothesized that hospitalized/ICU patients have higher respiratory virus viral loads compared to ambulatory (e.g. walk-in clinics, family practices)/ER patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b>
</p>
<p>We quantified viral load by in-house real-time RT-PCR in 774 nasopharyngeal swabs with influenza A/H3N2, or B or HRV viruses from various patient settings in Ontario, Canada.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Mean viral load (log</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>When compared to ambulatory/ER patients, viral load was higher in hospitalized/ICU patients with influenza B, but not influenza A or HRV.</p>
</div>
</front>
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<Month>01</Month>
<Day>03</Day>
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<Month>03</Month>
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<ArticleTitle>Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND">The role of viral load in respiratory viral infection is unclear. It is proposed that the viral load of some, but not all respiratory viruses correlate with disease severity.</AbstractText>
<AbstractText Label="OBJECTIVES">We aimed to determine if an association exists between viral loads among patients in ambulatory settings, compared to those requiring hospitalization/intensive care unit (ICU) admission with influenza A/H3N2, influenza B, or human rhinovirus (HRV); we also explored the impact of age, gender and co-detection of Streptococcus pneumoniae on patient setting. We hypothesized that hospitalized/ICU patients have higher respiratory virus viral loads compared to ambulatory (e.g. walk-in clinics, family practices)/ER patients.</AbstractText>
<AbstractText Label="STUDY DESIGN">We quantified viral load by in-house real-time RT-PCR in 774 nasopharyngeal swabs with influenza A/H3N2, or B or HRV viruses from various patient settings in Ontario, Canada.</AbstractText>
<AbstractText Label="RESULTS">Mean viral load (log<sub>10</sub>
 copies/ml) of influenza A/H3N2 (6.94) was higher than influenza B (4.96) and HRV (5.58) (p<0.0001). Influenza A/H3N2 viral loads were highest in infants and the elderly; however, increased A/H3N2 viral loads were not associated with hospitalization/ICU admission compared to swabs collected in ambulatory/ER settings. Influenza B viral loads were higher in patients in hospital/ICU settings compared to those in ambulatory settings (OR 1.28, 95% CI 1.11-1.47). HRV viral loads did not differ by age (p=0.67) or setting (p=0.54); there was no association between S. pneumoniae colonization and setting for any virus.</AbstractText>
<AbstractText Label="CONCLUSION">When compared to ambulatory/ER patients, viral load was higher in hospitalized/ICU patients with influenza B, but not influenza A or HRV.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Granados</LastName>
<ForeName>Andrea</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Public Health Ontario, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address: Andrea.granados@mail.utoronto.ca.</Affiliation>
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<ForeName>Adriana</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Public Health Ontario, Toronto, ON, Canada.</Affiliation>
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<ForeName>Allison</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Mount Sinai Hospital, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gubbay</LastName>
<ForeName>Jonathan B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Public Health Ontario, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; The Hospital for Sick Children, Toronto, ON, Canada.</Affiliation>
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<Month>11</Month>
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<MeshHeading><DescriptorName UI="D009975" MajorTopicYN="N">Orthomyxoviridae</DescriptorName>
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<MeshHeading><DescriptorName UI="D011008" MajorTopicYN="N">Pneumococcal Infections</DescriptorName>
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<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
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<MeshHeading><DescriptorName UI="D012229" MajorTopicYN="N">Rhinovirus</DescriptorName>
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<MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="Y">Viral Load</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Disease severity</Keyword>
<Keyword MajorTopicYN="Y">Influenza A</Keyword>
<Keyword MajorTopicYN="Y">Influenza B</Keyword>
<Keyword MajorTopicYN="Y">RT-qPCR</Keyword>
<Keyword MajorTopicYN="Y">Rhinovirus</Keyword>
<Keyword MajorTopicYN="Y">Viral load</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>10</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>11</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>11</Month>
<Day>21</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>11</Month>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
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<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27893998</ArticleId>
<ArticleId IdType="pii">S1386-6532(16)30603-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.jcv.2016.11.008</ArticleId>
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<affiliations><list><country><li>Canada</li>
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<region><li>Ontario</li>
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<settlement><li>Toronto</li>
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<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Granados, Andrea" sort="Granados, Andrea" uniqKey="Granados A" first="Andrea" last="Granados">Andrea Granados</name>
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<name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name>
<name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name>
<name sortKey="Peci, Adriana" sort="Peci, Adriana" uniqKey="Peci A" first="Adriana" last="Peci">Adriana Peci</name>
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Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections.

Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections.

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